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System Biosciences


System Biosciences,簡稱SBI,美國加州灣區新成立的生技公司,致力于獨特、創新生物技術之開發,以研發利于基因及蛋白質功能鑒定、研究之嶄新方法和工具為宗旨。 現階段研發重心為RNA干擾(RNAi)研究之相關工具。System Biosciences (SBI) 致力于開發獨特、革新的技術,為客戶研究蛋白組學和基因組學功能提供研究工具。SBI 是專業的慢病毒產品公司,提供基于慢病毒.


System Biosciences (SBI) develops innovative research tools for Vector delivery technologies, MicroRNA research, Exosome research, and Genome Engineering tools, including the CRISPR-Cas9 SmartNuclease? system and PrecisionX? HR targeting vectors. 


Highlights: 

Vector Technologies: 

? Powerful lentivector systems 

? One-step transfection piggyBac transposons 

? Single-copy gene additions with phiC31 integrase vectors 

? Sustained expression without integration with Minicircle DNA plasmids 

Exosome Research Tools: 

? Isolate exosomes with ExoQuick and ExoQuick-TC 

? Exo-Flow- Immunopurify exosomes on magentic beads and anlayze by FACS 

? Culture cells in exosome-depleted FBS

 ? Verify exosome recovery with antibodies 

? Quantitate exosomes with ELISAs 

Genome Engineering: 

? RNA-guided Cas9 SmartNuclease system 

? Fast and efficient mutation correction / gene editing 

? HR donor vectors for knock-in, knock-out & tagging 

? High-throughput, targeted integration with PinPoint technology 

Stem Cell Research: 

? iPSC reprogramming systems 

? Growth factors and media 

? Pluripotency confirmation kits and antibodies 

? iPS celllines, normal and disease models 

? Promoter lineage reporters in lentivectors 

Non-coding RNA: 

? LncRNA qPCR profiling kits 

? miRNome and OncoMir qPCR profiling systems 

? Lenti-miR Precursor clone libraries – arrayed and pooled 

? miRZip anti-miR clones for stable miRNA inhibition Exo-NGS 

Custom Service: 

? Provide serum, tissue culture media, or other patient biofluids to SBI 

? SBI isolates exosomes, purifies RNA and generates high quality NGS libraries 

? Sequencing performed using Illumina MiSeq and HiSeq platforms 

? Comprehensive data analysis, including generation of heat maps and top hits, provided 

? NGS data loaded onto a custom UCSC Genome Browser for convenient viewing.


產品列表:


Lentiviral Technology

  • Expression Vectors
  • Cumate Inducible Vectors
  • Transcription Reporter Vectors
  • Virus Production
  • Reporter Cell Lines

Genome Engineering

  • EZ-TAL Assembly Kit
  • Cas9 SmartNuclease
  • HR Donor Vectors
  • phiC31 Integrase System
  • PinPoint Targeting System
  • PiggyBac Transposon

Molecular Tools

  • Cold Fusion cloning
  • MetaMorph Mutagenesis Kit
  • mRNAExpress RNA Synthesis Kit
  • PureFection transfection
  • Retrovirus concentration
  • Cyto-Tracers
  • Molecular Imaging Vectors
  • MycoQuick

Minicircle Technology

Stem Cell Research

  • Growth Factors and Media
  • iPSC Reprogramming Systems
  • Antibody and AP Staining Kits
  • iPS Cell Lines
  • Pluripotency Reporters
  • Transdifferentiation Factors
  • Differentiation Reporters

MicroRNA Research

  • Expression Profiling
  • MicroRNA Overexpression
  • MicroRNA Knockdown
  • MicroRNA Virus Libraries
  • Target Selection System
  • Discovery & Cloning

Exosome Research

  • Exosome Isolation
  • Exosome FACS
  • Exosome-depleted FBS
  • Exosome Detection
  • Serum microRNAs

LncRNA Research

RNAi Libraries

  • Application Overview
  • Human Genome-wide
  • Mouse Genome-wide
  • Pathway Focused

Gene Analysis

  • RNA-Quant cDNA Synthesis
  • FullSpectrum
  • MultiStart Primers
  • Interferon Response Detection Kit

Immunology Research

  • Foxp3 vectors
  • RORyt vectors
  • T cell Reporters

 


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